GWAS-ROCS Database: Showing GR-Card for GR00388: Osteoarthritis (HGVRS6105)

Record Information

Version

1.0

Creation Date

2019-04-04 18:01:15 UTC

Last Updated

2020-04-06 20:49:12 UTC

GWAS-ROCS ID

GR00388

Study Information

Condition/Phenotype

Osteoarthritis

GWAS Central Data Set ID

HGVRS6105

PubMed ID

29559693

Meta-Analysis (Yes/No)

Control Subjects

190676

Case Subjects

9134

SNPs

Name	Odds Ratio	Allele Frequency	p-value
rs80057746	1.21576	0.0243844	1.0e-07
rs150365637	1.10607	0.117244	2.0e-07
rs7810100	1.08533	0.183686	6.0e-07
rs614332	1.06981	0.394666	1.0e-06
rs6557013	1.17485	0.958029	1.0e-06
rs111427307	1.28399	0.98017	2.0e-06
rs478255	1.07385	0.356363	2.0e-06
rs864839	1.08264	0.719223	2.0e-06
rs4377117	1.08073	0.779477	2.0e-06
rs12028630	1.07717	0.231693	3.0e-06
rs75659306	1.32786	0.987609	4.0e-06
rs4272700	1.06999	0.306727	4.0e-06
rs3771501	1.06703	0.474737	4.0e-06
rs114076575	1.24857	0.976415	5.0e-06
rs1205424	1.0665	0.679953	5.0e-06
rs11335718	1.11954	0.105579	5.0e-06
rs4688651	1.09813	0.14188	6.0e-06
rs1107427	1.0886	0.249427	6.0e-06
rs116784579	1.15249	0.941784	6.0e-06
rs4976875	1.07678	0.723421	6.0e-06
rs78693599	1.22461	0.0255466	7.0e-06
rs375575359	1.20181	0.0332962	7.0e-06
rs656127	1.0851	0.796649	8.0e-06
rs72740597	1.11742	0.914308	8.0e-06
rs231331	1.07862	0.22481	8.0e-06
rs7510312	1.0696	0.316499	9.0e-06
rs112347136	1.41993	0.989329	9.0e-06
rs508803	1.06531	0.472564	9.0e-06
rs4498002	1.06961	0.390667	9.0e-06

show all show less

Simulated Population

ROC Plot

AUROC

0.512727

Logistic Regression Equation

log(p/(1 - p)) = 12.566 + 0.231(rs80057746) + 0.145(rs150365637) + 0.055(rs7810100) - 0.103(rs614332) + 0.277(rs6557013) - 0.195(rs111427307) - 0.032(rs478255) - 0.192(rs864839) - 0.062(rs4377117) + 0.117(rs12028630) - 9.470(rs75659306) + 0.016(rs4272700) + 0.023(rs3771501) - 0.006(rs114076575) - 0.008(rs1205424) - 0.236(rs11335718) - 0.048(rs4688651) - 0.239(rs1107427) - 0.085(rs116784579) + 0.148(rs4976875) - 0.385(rs78693599) + 0.128(rs375575359) + 0.068(rs656127) - 0.031(rs72740597) - 0.052(rs231331) + 0.173(rs7510312) + 0.000(rs112347136) - 0.032(rs508803) + 0.056(rs4498002)

Heritability

0.001

Regression Type

OLS

Download File

GR00388.csv